Preheat the oven to 400°F (200°C) and lightly grease a casserole dish.
In a large skillet over medium heat, cook the ground beef and onion until the beef is no longer pink. Drain excess fat.
1 pound ground beef, 1 cup yellow onion
Stir in the taco seasoning, tomatoes, green chilies, sour cream, and cream of mushroom soup. Mix until well combined and heated through.
2 tablespoons mild taco seasoning, 1 ½ cups ripe tomatoes, 1 4-ounce can diced green chilies, adjust according to your preferred level of heat, 1 cup sour cream, 1 10.75-ounce can condensed cream of mushroom soup
In the prepared casserole dish, spread half of the beef mixture, then layer one-third of the crushed Doritos evenly over the top.
1 large bag of Doritos nacho cheese
Add the remaining beef mixture, then top with the remaining Doritos and sprinkle with shredded Jack cheese.
2 ½ cups Jack cheese
Bake uncovered for 20 minutes, or until hot and bubbly.
Let cool slightly, then serve warm.